abstract：BACKGROUND:The aim was to assess patient-reported outcomes (PROs) in patients with rheumatoid arthritis (RA) treated with filgotinib during two phase 2b, 24-week, randomized, placebo-controlled studies. METHODS:Patients with moderate-to-severe active RA and an inadequate response to methotrexate (MTX) were randomized ...

journal_title：Arthritis research & therapy

authors： Genovese M,Westhovens R,Meuleners L,Van der Aa A,Harrison P,Tasset C,Kavanaugh A

更新日期：2018-03-23 00:00:00

abstract：BACKGROUND:Galactosylation of immunoglobulin G (IgG) is reduced in rheumatoid arthritis (RA) and assumed to correlate with inflammation and altered humoral immunity. IgG hypogalactosylation also increases with age. To investigate dependencies in more detail, we compared IgG hypogalactosylation between patients with RA,...

journal_title：Arthritis research & therapy

authors： Schwedler C,Häupl T,Kalus U,Blanchard V,Burmester GR,Poddubnyy D,Hoppe B

更新日期：2018-03-14 00:00:00

abstract：BACKGROUND:Interstitial lung disease in systemic sclerosis (SSc-ILD) is a major cause of SSc-related death. Imunosuppressive treatment (IS) is used in patients with SSc for various organ manifestations mainly to ameliorate progression of SSc-ILD. Data on everyday IS prescription patterns and clinical courses of lung fu...

journal_title：Arthritis research & therapy

authors： Adler S,Huscher D,Siegert E,Allanore Y,Czirják L,DelGaldo F,Denton CP,Distler O,Frerix M,Matucci-Cerinic M,Mueller-Ladner U,Tarner IH,Valentini G,Walker UA,Villiger PM,Riemekasten G,EUSTAR co-workers on behalf of the DeSS

更新日期：2018-01-30 00:00:00

abstract：BACKGROUND:Interstitial lung disease (ILD) is the principal cause of death in polymyositis/dermatomyositis (PM/DM). Here we investigated prognostic factors for death and serious infection in PM/DM-ILD using the multicenter database. METHODS:We retrospectively reviewed baseline demographic, clinical and laboratory find...

journal_title：Arthritis research & therapy

authors： Sugiyama Y,Yoshimi R,Tamura M,Takeno M,Kunishita Y,Kishimoto D,Yoshioka Y,Kobayashi K,Takase-Minegishi K,Watanabe T,Hamada N,Nagai H,Tsuchida N,Soejima Y,Nakano H,Kamiyama R,Uehara T,Kirino Y,Sekiguchi A,Ihata A,O

更新日期：2018-01-11 00:00:00

abstract：BACKGROUND:We aimed to determine whether synovial fluid (SF) biomarkers can predict the progression of articular cartilage damage as determined by arthroscopic evaluation during and after anterior cruciate ligament (ACL) reconstruction. METHODS:Arthroscopic assessment of articular cartilage damage was performed twice ...

journal_title：Arthritis research & therapy

authors： Sobue Y,Kojima T,Kurokouchi K,Takahashi S,Yoshida H,Poole R,Ishiguro N

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:The aim was to further characterize immunoglobulin G4-related disease (IgG4-RD) by a large-scale multicenter study of its clinical and laboratory features conducted by multidisciplinary physicians of IgG4-RD in Japan. METHODS:Various specialists retrospectively evaluated IgG4-RD patients diagnosed between 1...

journal_title：Arthritis research & therapy

authors： Yamada K,Yamamoto M,Saeki T,Mizushima I,Matsui S,Fujisawa Y,Hara S,Takahashi H,Nomura H,Kawa S,Kawano M

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) and macrophages play an important role in rheumatoid arthritis (RA). Currently, it is not clear whether inflammatory M1 or anti-inflammatory M2 predominate among the resident macrophages in the synovium. In the present study, we set out to investigate the impact of TLR stimulation ...

journal_title：Arthritis research & therapy

authors： Quero L,Hanser E,Manigold T,Tiaden AN,Kyburz D

更新日期：2017-11-02 00:00:00

abstract：BACKGROUND:Ultrasound (US) is a sensitive method for detecting joint/tendon inflammation in patients with rheumatoid arthritis (RA). Subclinical inflammation is often found in patients with RA in composite score remission. The purpose of the present study was to explore whether US of only the hands is sufficient to ide...

journal_title：Arthritis research & therapy

authors： Hammer HB,Kvien TK,Terslev L

更新日期：2017-10-04 00:00:00

abstract：BACKGROUND:Comorbidities may contribute to disease activity and treatment response in rheumatoid arthritis (RA) patients. We defined a somatization comorbidity phenotype (SCP) and examined its influence on response to certolizumab pegol (CZP) using data from the PREDICT trial. METHODS:Patients in PREDICT were randomiz...

journal_title：Arthritis research & therapy

authors： Curtis JR,Herrem C,Ndlovu 'N,O'Brien C,Yazici Y

更新日期：2017-09-29 00:00:00

abstract：BACKGROUND:Currently, although several categories of biological disease-modifying antirheumatic drugs (bDMARDs) are available, there are few data informing selection of initial treatment for individual patients with rheumatoid arthritis (RA). Therefore, tumor necrosis factor inhibitor (TNF-i) and tocilizumab (TCZ) are ...

journal_title：Arthritis research & therapy

authors： Nakagawa J,Koyama Y,Kawakami A,Ueki Y,Tsukamoto H,Horiuchi T,Nagano S,Uchino A,Ota T,Akahoshi M,Akashi K

更新日期：2017-08-11 00:00:00

abstract：BACKGROUND:To understand the impact of yet undiagnosed non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) on work outcomes in a cohort of patients with long-lasting chronic low back pain (CLBP). METHODS:Data were used from a primary care CLBP cohort that was established to understand t...

journal_title：Arthritis research & therapy

authors： van Hoeven L,Boonen AERCH,Hazes JMW,Weel AEAM

更新日期：2017-06-17 00:00:00

abstract：BACKGROUND:Some abnormalities in nailfold videocapillaroscopy (NVC), such as the presence of micro-haemorrhages (MHEs), micro-thromboses (MTs), giant capillaries (GCs) and reduction in the number of capillaries (nCs), suggest a disease activity (DA) phase in systemic sclerosis (SSc). In a previous paper, we showed that...

journal_title：Arthritis research & therapy

authors： Andracco R,Irace R,Zaccara E,Vettori S,Maglione W,Riccardi A,Pignataro F,Ferrara R,Sambataro D,Sambataro G,Vitali C,Valentini G,Del Papa N

更新日期：2017-06-13 00:00:00

abstract：:One in six patients with systemic sclerosis will develop pulmonary arterial hypertension (PAH). Screening with echocardiography and possibly pulmonary function testing (to determine the diffusing capacity of carbon monoxide) is recommended to detect PAH at a less severe stage. However, real-world screening programs ha...

journal_title：Arthritis research & therapy

authors： Pope JE

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:Our previous study found that circulating and urinary levels of high mobility group box-1 (HMGB1) were closely associated with disease activity in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Moreover, HMGB1 participates in ANCA-induced neutrophil activation. Cross-re...

journal_title：Arthritis research & therapy

authors： Deng H,Wang C,Chang DY,Hu N,Chen M,Zhao MH

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:The receptor activator of NF-κB ligand (RANKL), a member of the TNF ligand superfamily, is known to regulate bone metabolism. The expression of each component of the RANK/RANKL/osteoprotegerin (OPG) system in the intervertebral disc (IVD) has not been examined in detail. The purposes of this study were to ex...

journal_title：Arthritis research & therapy

authors： Takegami N,Akeda K,Yamada J,Sano T,Murata K,Huang J,Masuda K,Sudo A

更新日期：2017-06-02 00:00:00

abstract：BACKGROUND:Evidence suggests lymphatic function mediates local rheumatoid arthritis (RA) flares. Yet biologics that target the immune system are dosed systemically via the subcutaneous (SC) administration route, thereby inefficiently reaching local lymphatic compartments. Nanotopography has previously been shown to dis...

journal_title：Arthritis research & therapy

authors： Aldrich MB,Velasquez FC,Kwon S,Azhdarinia A,Pinkston K,Harvey BR,Chan W,Rasmussen JC,Ross RF,Fife CE,Sevick-Muraca EM

更新日期：2017-05-31 00:00:00

abstract：BACKGROUND:Risk prediction algorithms increase understanding of which patients are at greatest risk of a harmful outcome. Our goal was to create a clinically useful prediction algorithm for structural progression of knee osteoarthritis (OA), using medial joint space loss as a proxy; and to quantify the benefit of inclu...

journal_title：Arthritis research & therapy

authors： LaValley MP,Lo GH,Price LL,Driban JB,Eaton CB,McAlindon TE

更新日期：2017-05-16 00:00:00

abstract：BACKGROUND:Tumor necrosis factor inhibitors (TNFi) are common second-line treatments for rheumatoid arthritis (RA). This study was designed to compare the real-world clinical and economic outcomes between patients with RA who responded to TNFi therapy and those who did not. METHODS:For this retrospective cohort analys...

journal_title：Arthritis research & therapy

authors： Grabner M,Boytsov NN,Huang Q,Zhang X,Yan T,Curtis JR

更新日期：2017-05-15 00:00:00

abstract：BACKGROUND:To aim was to investigate the additional value of incorporating the de Vlam cervical facet joint score in the modified ankylosing spondylitis (AS) spine score (mSASSS) for the evaluation of spinal radiographic outcome in AS. METHOD:Baseline and 4-year radiographs from 98 consecutive patients from the Gronin...

journal_title：Arthritis research & therapy

authors： Maas F,Arends S,Brouwer E,Bootsma H,Bos R,Wink FR,Spoorenberg A

更新日期：2017-04-26 00:00:00

abstract：BACKGROUND:We found recently that baseline signal transducer and activator of transcription 3 phosphorylation in peripheral blood CD4+ T cells of patients with early rheumatoid arthritis (RA) is associated with treatment response to synthetic disease-modifying antirheumatic drugs (DMARDs). This prompted us to study the...

journal_title：Arthritis research & therapy

authors： Kuuliala K,Kuuliala A,Koivuniemi R,Kautiainen H,Repo H,Leirisalo-Repo M

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:Social media may complement traditional data sources to answer comparative effectiveness/safety questions after medication licensure. METHODS:The Treato platform was used to analyze all publicly available social media data including Facebook, blogs, and discussion boards for posts mentioning inflammatory ar...

journal_title：Arthritis research & therapy

authors： Curtis JR,Chen L,Higginbotham P,Nowell WB,Gal-Levy R,Willig J,Safford M,Coe J,O'Hara K,Sa'adon R

更新日期：2017-03-07 00:00:00

abstract：BACKGROUND:The aim of this study was to understand whether acupuncture can decrease the risk of coronary heart disease (CHD) in patients with fibromyalgia. METHODS:Using data from the Taiwanese National Health Insurance Research Database, we performed a propensity score-matched cohort study to analyze patients with fi...

journal_title：Arthritis research & therapy

authors： Wu MY,Huang MC,Chiang JH,Sun MF,Lee YC,Yen HR

更新日期：2017-02-28 00:00:00

abstract：BACKGROUND:The aim was to describe the regulatory B and T cells (Breg and Treg) and T helper 17 (Th17) lymphocytes before and under treatment with biologic drugs, and to assess their potential predictive value as biomarkers of response in rheumatoid arthritis (RA). METHODS:This was a non-randomised, single-centre, pro...

journal_title：Arthritis research & therapy

authors： Salomon S,Guignant C,Morel P,Flahaut G,Brault C,Gourguechon C,Fardellone P,Marolleau JP,Gubler B,Goëb V

更新日期：2017-02-10 00:00:00

abstract：BACKGROUND:Determining the association between body composition and low back pain (LBP) will improve our understanding of the mechanisms by which obesity affects LBP, and inform novel approaches to managing LBP. The aim of this study was to examine the relationship between body composition and LBP intensity and disabi...

journal_title：Arthritis research & therapy

authors： Hussain SM,Urquhart DM,Wang Y,Shaw JE,Magliano DJ,Wluka AE,Cicuttini FM

更新日期：2017-02-10 00:00:00

abstract：BACKGROUND:Here we integrate verified signals from previous genetic association studies with gene expression and pathway analysis for discovery of new candidate genes and signaling networks, relevant for rheumatoid arthritis (RA). METHOD:RNA-sequencing-(RNA-seq)-based expression analysis of 377 genes from previously v...

journal_title：Arthritis research & therapy

authors： Shchetynsky K,Diaz-Gallo LM,Folkersen L,Hensvold AH,Catrina AI,Berg L,Klareskog L,Padyukov L

更新日期：2017-02-02 00:00:00

abstract：BACKGROUND:Restoring normal physical functioning is a major therapeutic aim in the management of rheumatoid arthritis (RA). It is unknown, whether the extent of synovial inflammation quantified by musculoskeletal ultrasound (US) can predict current or future capacity for physical functioning. To answer this question we...

journal_title：Arthritis research & therapy

authors： Závada J,Hánová P,Hurňáková J,Szczuková L,Uher M,Forejtová Š,Klein M,Mann H,Olejárová M,Růžičková O,Šléglová O,Hejduk K,Pavelka K

更新日期：2017-01-13 00:00:00

abstract：BACKGROUND:Increased circulatory levels of the chemokine CXCL4 have been associated with the presence of interstitial lung disease (ILD) in an observational study of patients with systemic sclerosis (SSc). The purpose of the present study was to evaluate the relationship between baseline CXCL4 level and extent of ILD i...

journal_title：Arthritis research & therapy

authors： Volkmann ER,Tashkin DP,Roth MD,Clements PJ,Khanna D,Furst DE,Mayes M,Charles J,Tseng CH,Elashoff RM,Assassi S

更新日期：2016-12-30 00:00:00

abstract：RESULTS:Anti-CarP antibodies were detected in 117 patients with RA (37.9%), ACPA in 190 patients (61.4%) and RF in 202 patients (65.3%). Two (2.04%) of the NHS were positive for anti-CarP, one NHS (1.02%) was positive for ACPA and three NHS were positive for RF (3.06%). Among disease controls, anti-CarP antibodies were...

journal_title：Arthritis research & therapy

authors： Pecani A,Alessandri C,Spinelli FR,Priori R,Riccieri V,Di Franco M,Ceccarelli F,Colasanti T,Pendolino M,Mancini R,Truglia S,Barbati C,Vomero M,Sabatinelli D,Morello F,Valesini G,Conti F

更新日期：2016-12-16 00:00:00

abstract：BACKGROUND:In this study, we evaluated the impact of obesity and/or overweight on the achievement of minimal disease activity (MDA) in patients with psoriatic arthritis (PsA) and patients with rheumatoid arthritis (RA) receiving an anti-rheumatic treatment. Obesity can be considered a low-grade, chronic systemic inflam...

journal_title：Arthritis research & therapy

authors： Lupoli R,Pizzicato P,Scalera A,Ambrosino P,Amato M,Peluso R,Di Minno MN

更新日期：2016-12-13 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) patients are treated with a mean of 3-4 conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) with or without glucocorticoids (GCs), before the first biologic prescription. The main reasons for change are inefficacy in 30-40 % of patients, and toxicity ≈ 10 %. Thus...

journal_title：Arthritis research & therapy

authors： Hernández-Cruz B,Márquez-Saavedra E,Caliz-Caliz R,Navarro-Sarabia F

更新日期：2016-11-08 00:00:00

abstract：BACKGROUND:BoneXpert (BX) is a newly developed medical device based on digital X-ray radiogrammetry to measure human cortical bone thickness. The aim of this study was to quantify cortical bone loss of the metacarpals in patients with psoriatic arthritis (PsA) and compare these findings with other radiological scoring ...

journal_title：Arthritis research & therapy

authors： Pfeil A,Krojniak L,Renz DM,Reinhardt L,Franz M,Oelzner P,Wolf G,Böttcher J

更新日期：2016-10-25 00:00:00

abstract：BACKGROUND:In some rheumatic diseases such as systemic lupus erythematosus (SLE), low serum complement ('hypocomplementaemia') is a feature of active disease. However, the role of hypocomplementaemia in systemic sclerosis (SSc) is unknown. We sought to determine the frequency, clinical associations and relationship to ...

journal_title：Arthritis research & therapy

authors： Esposito J,Brown Z,Stevens W,Sahhar J,Rabusa C,Zochling J,Roddy J,Walker J,Proudman SM,Nikpour M

更新日期：2016-10-22 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is characterized by early vascular abnormalities and subsequent fibroblast activation to myofibroblasts, leading to fibrosis. Recently, endothelial-to-mesenchymal transition (EndoMT), a complex biological process in which endothelial cells lose their specific markers and acquire a me...

journal_title：Arthritis research & therapy

authors： Corallo C,Cutolo M,Kahaleh B,Pecetti G,Montella A,Chirico C,Soldano S,Nuti R,Giordano N

更新日期：2016-10-06 00:00:00

abstract：BACKGROUND:Increased expression of toll-like receptor 4 (TLR4) and its endogenous ligands, is characteristic of rheumatoid arthritis (RA) synovitis. In this study, we evaluated how these TLR4 ligands may drive pathogenic processes and whether the fine profiling of anti-citrullinated protein antibodies (ACPA) based on t...

journal_title：Arthritis research & therapy

authors： Hatterer E,Shang L,Simonet P,Herren S,Daubeuf B,Teixeira S,Reilly J,Elson G,Nelson R,Gabay C,Sokolove J,McInnes IB,Kosco-Vilbois M,Ferlin W,Monnet E,De Min C

更新日期：2016-10-06 00:00:00

abstract：BACKGROUND:The detection of anti-dsDNA antibodies is critical for the diagnosis and follow-up of systemic lupus erythematosus (SLE) patients. The presently available assays are characterized by a non-optimal specificity (solid phase assays) or sensitivity (Crithidia Luciliae immunofluorescence test (CLIFT)). To overcom...

journal_title：Arthritis research & therapy

authors： Panza F,Alcaro MC,Petrelli F,Angelotti F,Pratesi F,Rovero P,Migliorini P

更新日期：2016-10-04 00:00:00

abstract：BACKGROUND:The idiopathic inflammatory myopathies (IIM) are autoimmune diseases characterised by acquired proximal muscle weakness, inflammatory cell infiltrates in muscle and myositis-specific/associated autoantibodies. It is unclear which pathways are involved in IIM, and the functional relationship between autoantib...

journal_title：Arthritis research & therapy

authors： Parkes JE,Rothwell S,Day PJ,McHugh NJ,Betteridge ZE,Cooper RG,Ollier WE,Chinoy H,Lamb JA,Myositis Genetics Consortium (MYOGEN).

更新日期：2016-07-07 00:00:00

abstract：BACKGROUND:Psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) are chronic inflammatory rheumatic diseases with complex origins. Both are characterized by altered extracellular matrix remodeling in joints and entheses that results in destructive and osteochondral proliferative lesions. There is a need for bio...

journal_title：Arthritis research & therapy

authors： Gudmann NS,Munk HL,Christensen AF,Ejstrup L,Sørensen GL,Loft AG,Karsdal MA,Bay-Jensen AC,He Y,Siebuhr AS,Junker P

更新日期：2016-06-16 00:00:00

abstract：BACKGROUND:The mechanisms underlying tolerance induction and maintenance in autoimmune arthritis remain elusive. In a mouse model of rheumatoid arthritis, collagen type II (CII)-induced arthritis, we explore the contribution of B cells to antigen-specific tolerance. METHODS:To generate expression of the CII-peptide sp...

journal_title：Arthritis research & therapy

authors： Andersson SE,Eneljung T,Tengvall S,Jirholt P,Stern A,Henningsson L,Liang B,Thorarinsdottir K,Kihlberg J,Holmdahl R,Mårtensson IL,Gustafsson K,Gjertsson I

更新日期：2016-06-14 00:00:00

abstract：BACKGROUND:This study aimed at investigating the effect of a resistance exercise intervention on the interstitial muscle levels of pro-inflammatory cytokines in fibromyalgia (FMS) and healthy controls (CON). METHODS:Twenty-four female patients with FMS (54 ± 8 years) and 27 female CON (54 ± 9 years) were subjected to ...

journal_title：Arthritis research & therapy

authors： Ernberg M,Christidis N,Ghafouri B,Bileviciute-Ljungar I,Löfgren M,Larsson A,Palstam A,Bjersing J,Mannerkorpi K,Kosek E,Gerdle B

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:Nearly all secreted proteins are glycosylated, and serum glycoproteins that exhibit disease-associated glycosylation changes have potential to be biomarkers. In rheumatoid arthritis (RA), C-reactive protein (CRP), and matrix metalloproteinase-3 (MMP-3) are widely used as serologic biomarkers, but they lack s...

journal_title：Arthritis research & therapy

authors： Takeshita M,Kuno A,Suzuki K,Matsuda A,Shimazaki H,Nakagawa T,Otomo Y,Kabe Y,Suematsu M,Narimatsu H,Takeuchi T

更新日期：2016-05-21 00:00:00